Research Articles
Predicting Neoadjuvant Chemotherapy Success: Biomarkers and Imaging for Early Response Assessment in Solid Tumors
This article provides a comprehensive review of strategies for the early assessment of neoadjuvant chemotherapy (NAC) response in solid tumors.
EGFR Imaging with ABY-029: A Comprehensive Guide to the Affibody Molecule for Researchers and Drug Developers
This article provides a detailed examination of ABY-029, a novel EGFR-targeting Affibody molecule labeled with a near-infrared fluorophore.
EGFR Receptor Availability in Glioma Models: From Basic Biology to Therapeutic Targeting
This comprehensive review examines the critical role of Epidermal Growth Factor Receptor (EGFR) availability in preclinical glioma models, addressing the needs of researchers and drug development professionals.
Decoding Dynamic Contrast-Enhanced (DCE) Imaging Kinetics: From Theory to Clinical Translation in Drug Development
This comprehensive guide explores Dynamic Contrast Agent Imaging Kinetics, focusing on its pivotal role in quantifying tissue microvasculature and physiology for researchers and drug development professionals.
Mastering Dual-Agent Kinetic Models: A Comprehensive Guide to Parameter Fitting for Drug Development
This article provides a comprehensive guide to fitting parameters in dual-agent kinetic models, a critical task in modern combination therapy development.
Beyond Binding: How Photoacoustic Imaging (PAI) is Revolutionizing Drug-Target Engagement in Live Systems
This article provides a comprehensive overview of Photoacoustic Imaging (PAI) as a transformative tool for monitoring drug-target engagement (DTE) in preclinical and clinical research.
Beyond the Energy Landscape: AI, Sampling, and HPC Strategies to Tame Computational Cost in Protein Structure Prediction
This article provides a comprehensive guide for researchers and drug development professionals navigating the high computational cost of global protein structure prediction.
DNA-Encoded Library Screening: A Step-by-Step Guide to Modern Protocols for Drug Discovery
This comprehensive guide for drug discovery researchers details the complete workflow for DNA-encoded library (DEL) screening, from foundational principles to advanced applications.
Unlocking Chemical Space for Drug Discovery: A Comprehensive Guide to DNA-Encoded Library (DEL) Screening
This article provides a complete overview of DNA-encoded library (DEL) technology for exploring ultra-large chemical space in modern drug discovery.
The Phosphorothioate Modification: Unveiling Prokaryotic DNA Backbone Sulfur for Drug Discovery and Genome Defense
This article provides a comprehensive review of DNA backbone sulfur modifications, specifically phosphorothioate (PT) linkages, in prokaryotes.